Samantha Stosur and Zhang Shuai defeated Coco Gauff and Caty McNally in the final, 6–3, 3–6, 6–3 to win the women's doubles title at the 2021 US Open.[1] It was Stosur's fourth major title in women's doubles and eighth major overall, as well as Zhang's second major title; this was the team's second major title, following the 2019 Australian Open. This was the first major final for Gauff and for McNally.
Laura Siegemund and Vera Zvonareva were the reigning champions,[2] but Siegemund did not participate due to injury. Zvonareva was scheduled to play partnering Jeļena Ostapenko, but Ostapenko withdrew from both the singles and doubles draws on the first day of the tournament.[3]
Bold denotes the mandatory tournaments (WTA 1000) † – Tournaments are affected by the COVID-19 pandemic * – Tournaments are introduced due to the impact of the COVID-19 pandemic