On 11 February, Salford began their Super League campaign with a 26–16 away win at Castleford Tigers[1] which they followed with a 38–12 win over Toulouse Olympique.[2] After this Salford began a poor run of results which saw them knocked out in the sixth round of the Challenge Cup[3] and fall to tenth in the table by early May.[4] However, their season then began to improve with back-to-back wins against Leeds Rhinos and Castleford[5] and although a win over Wakefield Trinity in June was seen as boosting their chances of survival,[6] by mid-July their win over Catalans Dragons was described in terms of them possibly reaching the play-offs.[7] A 44–12 upset of league leaders' St Helens[8] was part of a strong late season that also included wins over Huddersfield Giants and Castleford[9][10] and meant that Salford went into the final round of the regular season having already qualified for the play-offs and so named six debutants in the squad for their 32–14 loss to Warrington wolves.[11]
After finishing sixth in the table, Salford faced third-placed Huddersfield in the play-offs and defeated them 28–0 to set up a semi-final fixture with St Helens.[12] On 17 September, their season was ended at the Totally Wicked Stadium by a 19–12 loss to the defending champions.[13] At the 2022 Super League Awards on 20 September, Brodie Croft was named the Man of Steel.[14]