ACDC domain

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

AP2-Coincident Domain mainly at the Carboxy-terminus domain
AP2-Coincident Domain mainly at the Carboxy-terminus domain
Identifiers
Symbol	ACDC
Pfam	PF14733
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

The AP2-Coincident Domain mainly at the Carboxy-terminus, or ACDC domain, is a protein domain that occurs in proteins from apicomplexan parasites.^[1]

It is found exclusively in apicomplexan proteins that also contain AP2 (Apetala 2-integrase) DNA binding domains (ApiAP2 proteins). In 8 of 9 known examples in the malarial parasite Plasmodium falciparum it is near the carboxy terminus, with the remaining one being at the amino terminus. As yet, beyond its identification and the observation that it occurs only in ApiAP2 proteins, the function of the ACDC domain is unknown. Two proteins with the ACDC domain were found in the nucleus of P. falciparum, as detected by a proteomic method, suggesting a role in nuclear biology.^[1]

References

^ ^a ^b Oehring SC, Woodcroft BJ, Moes S, Wetzel J, Dietz O, Pulfer A, Dekiwadia C, Maeser P, Flueck C, Witmer K, Brancucci NM, Niederwieser I, Jenoe P, Ralph SA, Voss TS (November 2012). "Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum". Genome Biology. 13 (11): R108. doi:10.1186/gb-2012-13-11-r108. PMC 4053738. PMID 23181666.

[discovery-1] Oehring SC, Woodcroft BJ, Moes S, Wetzel J, Dietz O, Pulfer A, Dekiwadia C, Maeser P, Flueck C, Witmer K, Brancucci NM, Niederwieser I, Jenoe P, Ralph SA, Voss TS (November 2012). "Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum". Genome Biology. 13 (11): R108. doi:10.1186/gb-2012-13-11-r108. PMC 4053738. PMID 23181666.

[1]