Protein-coding gene in the species Homo sapiens
CCNC Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RGF , 4F6S , 4F6U , 4F6W , 4F70 , 4F7J , 4F7L , 4F7N , 4F7S , 4G6L , 4CRL , 5HBE , 5HBH , 5BNJ , 5HBJ , 5FGK , 5CEI , 5HNB , 5HVY , 5I5Z
Identifiers Aliases CCNC External IDs OMIM : 123838 ; MGI : 1858199 ; HomoloGene : 3803 ; GeneCards : CCNC ; OMA :CCNC - orthologs Wikidata
Cyclin-C is a protein that in humans is encoded by the CCNC gene .[ 5] [ 6]
The protein encoded by this gene is a member of the cyclin family of proteins . The encoded protein interacts with cyclin-dependent kinase 8 and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II . The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.[ 6]
Interactions
CCNC (gene) has been shown to interact with Estrogen receptor alpha [ 7] Cyclin-dependent kinase 8 .[ 7] [ 8] [ 9] [ 10] [ 11]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000112237 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028252 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lew DJ, Dulic V, Reed SI (Oct 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell . 66 (6): 1197–206. doi :10.1016/0092-8674(91)90042-W . PMID 1833066 . S2CID 12166415 . ^ a b "Entrez Gene: CCNC cyclin C" .^ a b Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro" . Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. Bibcode :2002PNAS...99.2642K . doi :10.1073/pnas.261715899 ISSN 0027-8424 . PMC 122401 PMID 11867769 . ^ Zhang, Y; Iratni R; Erdjument-Bromage H; Tempst P; Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex" . Cell . 89 (3): 357–64. doi :10.1016/S0092-8674(00)80216-0 ISSN 0092-8674 . PMID 9150135 . ^ Cho, H; Orphanides G; Sun X; Yang X J; Ogryzko V; Lees E; Nakatani Y; Reinberg D (Sep 1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure" . Mol. Cell. Biol . 18 (9): 5355–63. doi :10.1128/MCB.18.9.5355 . ISSN 0270-7306 . PMC 109120 PMID 9710619 . ^ Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract" . Mol. Cell. Biol . 21 (14): 4604–13. doi :10.1128/MCB.21.14.4604-4613.2001 . ISSN 0270-7306 . PMC 87123 PMID 11416138 . ^ Tassan, J P; Jaquenoud M; Léopold P; Schultz S J; Nigg E A (Sep 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C" . Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. Bibcode :1995PNAS...92.8871T . doi :10.1073/pnas.92.19.8871 ISSN 0027-8424 . PMC 41069 PMID 7568034 .
External links
Further reading
Nozawa T, Hatano M, Yamamoto H, Kwan T (1976). "Magnetic circular dichroism on the reversible oxygenation of dimethylmesoporphyrin-IX-atopyridinecobalt (II)". Bioinorganic Chemistry . 5 (3): 267–73. doi :10.1016/S0006-3061(00)82025-6 . PMID 1260071 . Tassan JP, Jaquenoud M, Léopold P, et al. (1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C" . Proc. Natl. Acad. Sci. U.S.A . 92 (19): 8871–5. Bibcode :1995PNAS...92.8871T . doi :10.1073/pnas.92.19.8871 PMC 41069 PMID 7568034 . Demetrick DJ, Matsumoto S, Hannon GJ, et al. (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet. Cell Genet . 69 (3–4): 190–2. doi :10.1159/000133960 . PMID 7698009 . Yoshizumi M, Lee WS, Hsieh CM, et al. (1995). "Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts" . J. Clin. Invest . 95 (5): 2275–80. doi :10.1172/JCI117918 . PMC 295840 PMID 7738192 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Rickert P, Seghezzi W, Shanahan F, et al. (1996). "Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II". Oncogene . 12 (12): 2631–40. PMID 8700522 . Li H, Lahti JM, Valentine M, et al. (1997). "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors". Genomics . 32 (2): 253–9. doi :10.1006/geno.1996.0112 . PMID 8833152 . Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme" . Mol. Cell. Biol . 17 (4): 1817–23. doi :10.1128/MCB.17.4.1817 . PMC 232028 PMID 9121429 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Neish AS, Anderson SF, Schlegel BP, et al. (1998). "Factors associated with the mammalian RNA polymerase II holoenzyme" . Nucleic Acids Res . 26 (3): 847–53. doi :10.1093/nar/26.3.847 . PMC 147327 PMID 9443979 . Cho H, Orphanides G, Sun X, et al. (1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure" . Mol. Cell. Biol . 18 (9): 5355–63. doi :10.1128/MCB.18.9.5355 . PMC 109120 PMID 9710619 . Sun X, Zhang Y, Cho H, et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription" . Mol. Cell . 2 (2): 213–22. doi :10.1016/S1097-2765(00)80131-8 PMID 9734358 . Gu W, Malik S, Ito M, et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation" . Mol. Cell . 3 (1): 97–108. doi :10.1016/S1097-2765(00)80178-1 PMID 10024883 . Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators" . Mol. Cell . 3 (3): 361–70. doi :10.1016/S1097-2765(00)80463-3 PMID 10198638 . Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature . 398 (6730): 824–8. Bibcode :1999Natur.398..824R . doi :10.1038/19783 . PMID 10235266 . S2CID 204992765 . Wang G, Cantin GT, Stevens JL, Berk AJ (2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract" . Mol. Cell. Biol . 21 (14): 4604–13. doi :10.1128/MCB.21.14.4604-4613.2001 . PMC 87123 PMID 11416138 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3" (PDF) . J. Biol. Chem . 278 (17): 15123–7. doi :10.1074/jbc.C300054200 PMID 12584197 . Ueberham U, Hessel A, Arendt T (2003). "Cyclin C expression is involved in the pathogenesis of Alzheimer's disease". Neurobiol. Aging . 24 (3): 427–35. doi :10.1016/S0197-4580(02)00132-X . PMID 12600719 . S2CID 12604491 .
