DYRK1B

DYRK1B
Identifiers
Aliases	DYRK1B, AOMS3, MIRK, dual specificity tyrosine phosphorylation regulated kinase 1B
External IDs	OMIM: 604556; MGI: 1330302; HomoloGene: 31253; GeneCards: DYRK1B; OMA:DYRK1B - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,834,201 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	27,886,719 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; skeletal muscle tissue; ; right testis; ; left testis; ; gastrocnemius muscle; ; right uterine tube; ; Pituitary Gland; ; right adrenal gland; ; anterior pituitary; ; right adrenal cortex;
	Top expressed in
	spermatid; ; muscle of thigh; ; spermatocyte; ; seminiferous tubule; ; neural layer of retina; ; genital tubercle; ; lip; ; superior frontal gyrus; ; skeletal muscle tissue; ; granulocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; transcription coactivator activity; protein serine/threonine/tyrosine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; nucleotide binding; protein binding; ATP binding; kinase activity;
Cellular component	nucleus;
Biological process	positive regulation of transcription, DNA-templated; protein phosphorylation; peptidyl-tyrosine phosphorylation; myoblast fusion; adipose tissue development; phosphorylation; protein autophosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	9149
	13549
	ENSG00000105204; ENSG00000281320
	ENSMUSG00000002409
	Q9Y463
	Q9Z188
	NM_004714; NM_006483; NM_006484
	NM_001037957; NM_001271370; NM_010092
	NP_004705; NP_006474; NP_006475; NP_004705.1
	NP_001033046; NP_001258299; NP_034222
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the DYRK1B gene.^[5]^[6]

Function

DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain.^[6]

Interactions

DYRK1B has been shown to interact with:

PCBD1^[7] and
RANBP9.^[8]

Clinical significance

One lone missense mutation in Dyrk1B gene (R102C) was found associated with an autosomal dominant early onset Coronary Artery Disease, juvenile-onset truncal obesity, severe hypertension, and type II diabetes mellitus - seen in subjects from a nomadic group in Iran.^[9]

References

^ ^a ^b ^c ENSG00000281320 GRCh38: Ensembl release 89: ENSG00000105204, ENSG00000281320 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002409 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Leder S, Weber Y, Altafaj X, Estivill X, Joost HG, Becker W (Feb 1999). "Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases". Biochem Biophys Res Commun. 254 (2): 474–9. doi:10.1006/bbrc.1998.9967. PMID 9918863.
^ ^a ^b "Entrez Gene: DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B".
^ Lim S, Jin K, Friedman E (Jul 2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha". J. Biol. Chem. 277 (28): 25040–6. doi:10.1074/jbc.M203257200. PMID 11980910.
^ Zou Y, Lim S, Lee K, Deng X, Friedman E (Dec 2003). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M". J. Biol. Chem. 278 (49): 49573–81. doi:10.1074/jbc.M307556200. PMID 14500717.
^ Keramati AR; et al. (2013). "Identification of a Novel Disease Gene for Early Onset Atherosclerosis, Diabetes and Metabolic Syndrome by Whole Exome Sequencing and Linkage Analysis". Circulation. 128 (22 Supplement).

Mercer SE, Friedman E (2006). "Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival". Cell Biochem. Biophys. 45 (3): 303–15. doi:10.1385/CBB:45:3:303. PMID 16845176.
Lee K, Deng X, Friedman E (2000). "Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells". Cancer Res. 60 (13): 3631–7. PMID 10910078.
Lim S, Jin K, Friedman E (2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha". J. Biol. Chem. 277 (28): 25040–6. doi:10.1074/jbc.M203257200. PMID 11980910.
Lim S, Zou Y, Friedman E (2003). "The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase". J. Biol. Chem. 277 (51): 49438–45. doi:10.1074/jbc.M206840200. PMID 12384504.
Zou Y, Lim S, Lee K, Deng X, Friedman E (2004). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M." J. Biol. Chem. 278 (49): 49573–81. doi:10.1074/jbc.M307556200. PMID 14500717.
Skurat AV, Dietrich AD (2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol. Chem. 279 (4): 2490–8. doi:10.1074/jbc.M301769200. PMID 14593110.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Deng X, Ewton DZ, Mercer SE, Friedman E (2005). "Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation". J. Biol. Chem. 280 (6): 4894–905. doi:10.1074/jbc.M411894200. PMID 15546868.
Mercer SE, Ewton DZ, Deng X, Lim S, Mazur TR, Friedman E (2005). "Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts". J. Biol. Chem. 280 (27): 25788–801. doi:10.1074/jbc.M413594200. PMC 1201501. PMID 15851482.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Deng X, Ewton DZ, Li S, Naqvi A, Mercer SE, Landas S, Friedman E (2006). "The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma". Cancer Res. 66 (8): 4149–58. doi:10.1158/0008-5472.CAN-05-3089. PMID 16618736.
Takahashi-Yanaga F, Mori J, Matsuzaki E, Watanabe Y, Hirata M, Miwa Y, Morimoto S, Sasaguri T (2007). "Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells". J. Biol. Chem. 281 (50): 38489–97. doi:10.1074/jbc.M605205200. PMID 17046823.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000281320 GRCh38: Ensembl release 89: ENSG00000105204, ENSG00000281320 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002409 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9918863-5] Leder S, Weber Y, Altafaj X, Estivill X, Joost HG, Becker W (Feb 1999). "Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases". Biochem Biophys Res Commun. 254 (2): 474–9. doi:10.1006/bbrc.1998.9967. PMID 9918863.

[entrez-6] "Entrez Gene: DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B".

[pmid11980910-7] Lim S, Jin K, Friedman E (Jul 2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha". J. Biol. Chem. 277 (28): 25040–6. doi:10.1074/jbc.M203257200. PMID 11980910.

[pmid14500717-8] Zou Y, Lim S, Lee K, Deng X, Friedman E (Dec 2003). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M". J. Biol. Chem. 278 (49): 49573–81. doi:10.1074/jbc.M307556200. PMID 14500717.

[9] Keramati AR; et al. (2013). "Identification of a Novel Disease Gene for Early Onset Atherosclerosis, Diabetes and Metabolic Syndrome by Whole Exome Sequencing and Linkage Analysis". Circulation. 128 (22 Supplement).

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DYRK1B

Function

Interactions

Clinical significance

See also

References

Further reading