After the War of Independence, which started in 1821, Greece was declared an independent state but it was not until 3 February 1830 that the Independence was recognized by the Great Powers with the signing of the Protocol of London. On 7 May 1832 Otto of Greece arrived in Nafplion and Greece became a Kingdom. The United States, however, recognized the Greek state only in 1833. In December 1837 a commercial treaty was signed, which regulated trade between the two countries. The first Greek consulate to be established was that of New Orleans, in 1866. Records indicate that Nicolas Benachi was the first Greek consul in New Orleans. In 1867, Demetrios Nicholas Botassis was named Consul General of Greece in New York City.
The embassy is also responsible for other eight Greek diplomatic missions (six consulates-general and two consulates) throughout the United States, each one responsible for certain states:
^Owing three separate buildings, several of the embassy's sections are located in different addresses; 2211, 2217, 2228 Massachusetts Avenue are the other addresses