At the review aggregator website Book Marks, which assigns individual ratings to book reviews from mainstream literary critics, the novel received a cumulative "Positive" rating based on 31 reviews: 11 "Rave" reviews, 14 "Positive" reviews, 5 "Mixed" reviews, and 1 "Pan" review.[8][9][10]
Writing for The Guardian, British novelist Sam Byers gave the novel a rave review, praising Winterson's ability "to leaven the hyperinvention of rogue science with deeply evocative historical realism."[12]
Sarah Lotz, writing for The New York Times Book Review, praised Winterson's scenes of Mary Shelley as "visceral and seeped with Gothic gloom" and called the novel "both deeply thought-provoking and provocative yet also unabashedly entertaining."[13]
Ron Charles of The Washington Post gave the novel a rave review, praising its dialogue and calling it "an unholy amalgamation of scholarship and comedy."[14]
Holly Williams of The Independent gave the novel a positive review, calling it "enjoyably audacious" but also felt it to be "overstuffed" with Winterson's research and its satiric dialogue "too crude to be convincing."[15]
Sam Sacks of The Wall Street Journal gave the novel a favourable review, writing, "This is a book whose mismatched parts—subtle historical drama and philosophical allegory; bawdy humor and profound moral inquiries—somehow combine to form a powerful, living whole."[16]
Writing in the New Statesman, Ben Myers panned the novel, criticizing it for Winterson's "cramming in of so many ethical and philosophical points of discussion, often by way of didactic and totally implausible dialogue [...] it feels as if Winterson is playing to the contemporary woke crowd."[17]
Frankissstein: Eine Liebesgeschichte (in German). Translated by Walitzek, Brigitte; Grabinger, Michaela. Germany: Kein & Aber. 8 October 2019. ISBN978-3-0369-5810-1.[19]
Frankissstein: una historia de amor (in Spanish). Translated by Martín de Dios, Laura. Spain: Editorial Lumen (published 7 November 2019). 24 March 2020. ISBN978-84-264-0643-9.[20]
Frankissstein: una storia d'amore (in Italian). Translated by Spallino Rocca, Chiara. Italy: Mondadori (published 12 November 2019). 2019. ISBN9788804718628.[21]
Frankissstein: una història d'amor (in Catalan). Translated by Udina, Dolors. Catalonia: Edicions del Periscopi. November 2019. ISBN978-84-17339-29-6.[22]