In week ten of the 2019 season, Holani got his first career start against San Jose State where he rushed for 126 yards and four touchdowns.[3] For his performance in his freshman season he was named the Mountain West Freshman of the Year.[4] Also in 2019 he was named second team all-Mountain West.[5] In Holani's first three seasons in 2019, 2020, and 2021 he rushed for 1,691 yards and nine touchdowns, while also making 47 receptions for 427 yards and five touchdowns.[6] During the 2022 season, Holani rushed for 1,157 yards and ten touchdowns, while also bringing in 24 receptions for 151 yards and three touchdowns.[7] For his performance on the 2022 season, Holani was named second-team all-Mountain West.[8] During the 2023 season, Holani rushed for 748 yards and seven touchdowns, while also bringing in 17 receptions for 199 yards.[9] After the conclusion of the 2023 season, Holani declared for the 2024 NFL draft.[10] Holani participated in the 2024 NFL combine after receiving an invite.[11]
Holani finished his Boise State career with 3,569 rushing yards and 26 touchdowns, while also hauling in 88 receptions for 777 yards and eight touchdowns.[12]
Holani signed with the Seattle Seahawks as an undrafted free agent on May 3, 2024.[15] He was waived on August 27, and re-signed to the practice squad.[16][17] On December 26, Holani was signed to the active roster after Kenneth Walker III was placed on injured reserve.[18]