British statistical geneticist (born 1973)
Gilean Alistair Tristram McVean FRS FMedSci [ 5] [ 6] genetics at the University of Oxford ,[ 7] Linacre College, Oxford and co-founder and director of Genomics plc .[ 6] [ 8] 1000 Genomes Project analysis group.[ 9] [ 10]
Education
Gilean McVean speaking at the 2010 GEM meeting at the Wellcome Trust Sanger Institute, Hinxton From 1991-94, he completed a Bachelor of Arts degree in Biological Sciences at the University of Oxford.[ 11] PhD in the Department of Genetics at the University of Cambridge supervised by Laurence Hurst [ 12] [ 13] [ 3] [ 14]
Career and research
McVean completed postdoctoral research at the University of Edinburgh from 1997 to 2000, supervised by Brian and Deborah Charlesworth .[ 15] [ 14]
From 2000-04, he was a Royal Society University Research Fellow in the Department of Statistics at Oxford, where he has also been a University lecturer in Mathematical Genetics since 2004. He was reappointed in 2009 until retirement age.[ 16] [ 17]
McVean's research[ 18] population genetics , statistics[ 19] evolutionary biology including the International HapMap Project ,[ 20] [ 21] human genome [ 22] 1000 Genomes Project .[ 23] [ 24]
McVean developed a statistical method to look at recombination rate which helped to identify PRDM9 as a hotspot positioning gene.[ 25] Peter Donnelly , McVean co-founded Genomics plc, a genomics analysis company, as a corporate spin-off of the University of Oxford.[ 6] Big Data Institute at the University of Oxford.[ 26]
Honours and awards
In 2006 McVean was awarded a Philip Leverhulme Prize .[ 27] [ 28]
In 2010, McVean was awarded the Francis Crick Medal and delivered that year's lecture entitled "Our genomes, our history".[ 29]
In 2012, he was awarded the Weldon Memorial Prize .[ 30]
In 2013, he presented a talk TEDxWarwick entitled A Thousand Genomes a Thousand Stories .[ 31]
In May 2014, McVean was elected as a member of the European Molecular Biology Organisation .[ 32]
McVean was elected Fellow of the Royal Society (FRS) in 2016 [ 5] Fellow of the Academy of Medical Sciences (FMedSci).[ 33] [ 34]
References
^ "Francis Crick Medal and Lecture 2010 - Our genomes, our history" . Royal Society . Retrieved 27 January 2022 .^ Hurst, L.; McVean, G. (1996). "A difficult phase for introns-early. Molecular evolution" . Current Biology . 6 (5): 533– 36. doi :10.1016/S0960-9822(02)00535-3 PMID 8805261 . ^ a b McVean, Gilean Alistair Tristram (1998). Adaptation and conflict: the differences between the sexes in mammalian genome evolution OCLC 894602716 . Archived from the original on 11 February 2022. Retrieved 15 May 2015 . ^ "Students and post-docs past and present in the Hurst laboratory" . University of Bath. Archived from the original on 15 May 2015.^ a b Anon (2016). "Gilean McVean" . royalsociety.org . London: Royal Society . Archived from the original on 29 April 2016. ^ a b c Anon (2016). "Gilean MCVEAN Profile" . companieshouse.gov.uk . London: Companies House . Archived from the original on 12 August 2016. ^ "McVean Group at the University of Oxford" . Archived from the original on 29 January 2009. Retrieved 19 February 2009 .^ "Prof. Gil McVean - GENOMICS plc" . Retrieved 30 December 2017 .^ "Oct 10: 1000 Genomes project - Wellcome Trust Centre for Human Genetics" . www.well.ox.ac.uk . Archived from the original on 10 September 2018. Retrieved 30 December 2017 .^ Gil McVean publications from Europe PubMed Central ^ Gil McVean's ORCID 0000-0002-5012-4162
^ McVean, G.T.; Hurst, L.D. (1997). "Evidence for a selectively favourable reduction in the mutation rate of the X chromosome". Nature . 386 (6623): 388– 92. Bibcode :1997Natur.386..388M . doi :10.1038/386388a0 . PMID 9121553 . S2CID 4343123 . ^ Hurst, L.D.; McVean, G.T. (1996). "...And scandalous symbionts" . Nature . 381 (6584): 650– 51. Bibcode :1996Natur.381..650H . doi :10.1038/381650a0 PMID 8649507 . ^ a b "Gilean McVean profile" . Oxford University . Archived from the original on 24 October 2017. Retrieved 30 December 2017 .^ Charlesworth, D.; Charlesworth, B.; McVean, G. (2001). "Genome sequences and evolutionary biology, a two-way interaction". Trends in Ecology & Evolution . 16 (5): 235– 42. doi :10.1016/S0169-5347(01)02126-7 . PMID 11301152 . ^ "Oxford University Gazette - Reappointments" . ox.ac.uk . 14 May 2009. Archived from the original on 30 May 2009. Retrieved 30 December 2017 .^ "Oxford University Gazette" . ox.ac.uk . Archived from the original on 2 October 2013. Retrieved 12 July 2016 .^ Gilean McVean profile , Google Scholar ; accessed 30 December 2017.^ Reshef, D. N.; Reshef, Y. A.; Finucane, H. K.; Grossman, S. R.; McVean, G. ; Turnbaugh, P. J.; Lander, E. S. ; Mitzenmacher, M.; Sabeti, P. C. (2011). "Detecting Novel Associations in Large Data Sets" . Science . 334 (6062): 1518– 1524. Bibcode :2011Sci...334.1518R . doi :10.1126/science.1205438 . PMC 3325791 PMID 22174245 . ^ Frazer, K. A.; Frazer, D. G.; Ballinger, D. R.; Cox, D. A.; Hinds, L. L.; Stuve, R. A.; Gibbs, J. W.; Belmont, A.; Boudreau, P.; Hardenbol, S. M.; Leal, S.; Pasternak, D. A.; Wheeler, T. D.; Willis, F.; Yu, H.; Yang, C.; Zeng, Y.; Gao, H.; Hu, W.; Hu, C.; Li, W.; Lin, S.; Liu, H.; Pan, X.; Tang, J.; Wang, W.; Wang, J.; Yu, B.; Zhang, Q.; et al. (2007). "A second generation human haplotype map of over 3.1 million SNPs" . Nature . 449 (7164): 851– 61. Bibcode :2007Natur.449..851F . doi :10.1038/nature06258 . PMC 2689609 PMID 17943122 . ^ Sabeti, Pardis C. ; Varilly, Patrick; Fry, Ben; Lohmueller, Jason; Hostetter, Elizabeth; Cotsapas, Chris; Xie, Xiaohui; Byrne, Elizabeth H.; McCarroll, Steven A.; Gaudet, Rachelle; Schaffner, Stephen F.; Lander, Eric S.; The International HapMap Consortium; Frazer, Kelly A.; Ballinger, Dennis G.; Cox, David R.; Hinds, David A.; Stuve, Laura L.; Gibbs, Richard A.; Belmont, John W.; Boudreau, Andrew; Hardenbol, Paul; Leal, Suzanne M.; Pasternak, Shiran; Wheeler, David A.; Willis, Thomas D.; Yu, Fuli; Yang, Huanming; Zeng, Changqing Zeng; et al. (2007). "Genome-wide detection and characterization of positive selection in human populations" . Nature . 449 (7164): 913– 918. Bibcode :2007Natur.449..913S . doi :10.1038/nature06250 . PMC 2687721 PMID 17943131 .^ McVean, G. A. T.; Myers, S.; Hunt, S.; Deloukas, P.; Bentley, D.; Donnelly, P. (2004). "The Fine-Scale Structure of Recombination Rate Variation in the Human Genome". Science . 304 (5670): 581– 584. Bibcode :2004Sci...304..581M . doi :10.1126/science.1092500 . PMID 15105499 . S2CID 20616898 . ^ Danecek, P.; Auton, A.; Abecasis, G.; Albers, C. A.; Banks, E.; Depristo, M. A.; Handsaker, R.; Lunter, G.; Marth, G.; Sherry, S. T.; McVean, G.; Durbin, R.; 1000 Genomes Project Analysis Group (2011). "The Variant Call Format and VCFtools" . Bioinformatics . 27 (15): 2156– 58. doi :10.1093/bioinformatics/btr330 . PMC 3137218 PMID 21653522 . {{cite journal }}: CS1 maint: numeric names: authors list (link )^ Hernandez, R. D.; Kelley, J. L.; Elyashiv, E.; Melton, S. C.; Auton, A.; McVean, G.; 1000 Genomes Project; Sella, G.; Przeworski, M. (2011). "Classic Selective Sweeps Were Rare in Recent Human Evolution" . Science . 331 (6019): 920– 24. Bibcode :2011Sci...331..920H . doi :10.1126/science.1198878 . PMC 3669691 PMID 21330547 . {{cite journal }}: CS1 maint: numeric names: authors list (link )^ "Gilean McVean" . royalsociety.org . Retrieved 30 December 2017 .^ "Professor Cecilia Lindgren appointed Director of the Big Data Institute — Oxford Big Data Institute" . www.bdi.ox.ac.uk . Retrieved 29 April 2021 .^ "AWARDS MADE IN 2006" (PDF) . leverhulme.ac.uk . The Leverhulme Trust. 2006. Archived from the original (PDF) on 10 August 2016. Retrieved 30 December 2017 .^ "Philip Leverhulme Prizes 2006" (PDF) . leverhulme.ac.uk . The Leverhulme Trust. 2006. Retrieved 30 December 2017 .^ The Royal Society (10 December 2013), Our genomes, our history archived from the original on 15 December 2021, retrieved 30 December 2017 ^ "Professor Gil McVean awarded the Weldon Memorial Prize 2012 - Wellcome Trust Centre for Human Genetics" . well.ox.ac.uk . Retrieved 30 December 2017 .^ TEDx Talks (29 March 2013), A Thousand Genomes a Thousand Stories: Gilean McVean at TEDxWarwick 2013 archived from the original on 15 December 2021, retrieved 30 December 2017 ^ "EMBO enlarges its membership for 50th anniversary" . embo.org . Retrieved 30 December 2017 .^ "New Fellows: Academy of Medical Sciences" . acmedsci.ac.uk . Retrieved 30 December 2017 .^ "Professor Gil McVean elected a Fellow of the Royal Society - GENOMICS plc" . Retrieved 30 December 2017 .
International National Academics
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