OPN1MW

OPN1MW
Identifiers
Aliases	OPN1MW, CBBM, CBD, COD5, GCP, GOP, OPN1MW1, opsin 1 (cone pigments), medium-wave-sensitive, opsin 1, medium wave sensitive
External IDs	OMIM: 300821; MGI: 1097692; HomoloGene: 88332; GeneCards: OPN1MW; OMA:OPN1MW - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	154,196,861 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	73,194,366 bp
RNA expression pattern
	Top expressed in
	testicle; ; appendix; ; blood; ; urinary bladder; ; myometrium; ; left adrenal cortex; ; coronary artery; ; left coronary artery; ; right auricle; ; stomach;
	Top expressed in
	neural layer of retina; ; muscle of thigh; ; retinal pigment epithelium; ; epithelium of lens; ; embryo; ; outer nuclear layer; ; knee joint; ; soleus muscle; ; skeletal muscle tissue; ; quadriceps femoris muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; photoreceptor activity; signal transducer activity; G protein-coupled photoreceptor activity; identical protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; photoreceptor outer segment; integral component of plasma membrane; photoreceptor disc membrane;
Biological process	positive regulation of cytokinesis; signal transduction; visual perception; retinoid metabolic process; response to stimulus; G protein-coupled receptor signaling pathway; phototransduction; detection of visible light; cellular response to light stimulus;
	Sources:Amigo / QuickGO
Orthologs
	2652
	14539
	ENSG00000268221
	ENSMUSG00000031394
	P04001; P0DN77; P0DN78
	O35599
	NM_000513
	NM_008106
NP_001316996; NP_000504; NP_001041646; NP_000504.1; NP_001041646.1;
	NP_000504; NP_001041646; NP_000504.1; NP_001041646.1; NP_000504; NP_001041646
	NP_032132
	Wikidata
View/Edit Human	View/Edit Mouse

Green-sensitive opsin is a protein that in humans is encoded by the OPN1MW gene.^[5] OPN1MW2 is a similar opsin.

The OPN1MW gene provides instructions for making an opsin pigment that is more sensitive to light in the middle of the visible spectrum (yellow/green light).^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000268221 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031394 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: OPN1MW opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)".
^ https://medlineplus.gov/genetics/gene/opn1mw/

Applebury ML, Hargrave PA (1987). "Molecular biology of the visual pigments". Vision Res. 26 (12): 1881–95. doi:10.1016/0042-6989(86)90115-X. PMID 3303660. S2CID 34038855.
Winderickx J, Sanocki E, Lindsey DT, et al. (1993). "Defective colour vision associated with a missense mutation in the human green visual pigment gene". Nat. Genet. 1 (4): 251–6. doi:10.1038/ng0792-251. PMID 1302020. S2CID 23127406.
Neitz J, Neitz M, Jacobs GH (1990). "Analysis of fusion gene and encoded photopigment of colour-blind humans". Nature. 342 (6250): 679–82. doi:10.1038/342679a0. PMID 2574415. S2CID 4273929.
Nathans J, Thomas D, Hogness DS (1986). "Molecular genetics of human color vision: the genes encoding blue, green, and red pigments". Science. 232 (4747): 193–202. Bibcode:1986Sci...232..193N. CiteSeerX 10.1.1.461.5915. doi:10.1126/science.2937147. PMID 2937147.
Li ZY, Kljavin IJ, Milam AH (1995). "Rod photoreceptor neurite sprouting in retinitis pigmentosa". J. Neurosci. 15 (8): 5429–38. doi:10.1523/JNEUROSCI.15-08-05429.1995. PMC 6577619. PMID 7643192.
Ladekjaer-Mikkelsen AS, Rosenberg T, Jørgensen AL (1996). "A new mechanism in blue cone monochromatism". Hum. Genet. 98 (4): 403–8. doi:10.1007/s004390050229. PMID 8792812. S2CID 11799731.
Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin". Nature. 383 (6601): 637–40. Bibcode:1996Natur.383..637F. doi:10.1038/383637a0. PMID 8857542. S2CID 4304490.
Vissers PM, Bovee-Geurts PH, Portier MD, et al. (1998). "Large-scale production and purification of the human green cone pigment: characterization of late photo-intermediates". Biochem. J. 330 (3): 1201–8. doi:10.1042/bj3301201. PMC 1219262. PMID 9494086.
Bernstein SL, Wong P (1998). "Regional expression of disease-related genes in human and monkey retina". Mol. Vis. 4: 24. PMID 9815288.
Hayashi T, Motulsky AG, Deeb SS (1999). "Position of a 'green-red' hybrid gene in the visual pigment array determines colour-vision phenotype". Nat. Genet. 22 (1): 90–3. doi:10.1038/8798. PMID 10319869. S2CID 1326234.
Ueyama H, Kuwayama S, Imai H, et al. (2002). "Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies". Biochem. Biophys. Res. Commun. 294 (2): 205–9. doi:10.1016/S0006-291X(02)00458-8. PMID 12051694.
Zhu X, Brown B, Li A, et al. (2003). "GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina". J. Neurosci. 23 (14): 6152–60. doi:10.1523/JNEUROSCI.23-14-06152.2003. PMC 6740345. PMID 12853434.
Bonilha VL, Hollyfield JG, Grover S, Fishman GA (2005). "Abnormal distribution of red/green cone opsins in a patient with an autosomal dominant cone dystrophy". Ophthalmic Genet. 26 (2): 69–76. doi:10.1080/13816810590968041. PMID 16020309. S2CID 24486298.

External links

GeneReviews/NIH/NCBI/UW entry on Red-Green Color Vision Defects

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000268221 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031394 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OPN1MW opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)".

[6] ttps://medlineplus.gov/genetics/gene/opn1mw/

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OPN1MW

See also

References

Further reading

External links

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