Protein-coding gene in the species Homo sapiens
PPP3CA Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AUI , 1M63 , 1MF8 , 2JOG , 2JZI , 2P6B , 2R28 , 2W73 , 3LL8 , 4F0Z , 4Q5U , 5C1V
Identifiers Aliases PPP3CA , CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B, protein phosphatase 3 catalytic subunit alpha, IECEE, IECEE1, ACCIID, DEE91External IDs OMIM : 114105 ; MGI : 107164 ; HomoloGene : 55497 ; GeneCards : PPP3CA ; OMA :PPP3CA - orthologs RNA expression patternBgee Human Mouse (ortholog)Top expressed in Brodmann area 23 endothelial cell middle temporal gyrus Region I of hippocampus proper postcentral gyrus Brodmann area 46 entorhinal cortex orbitofrontal cortex external globus pallidus Pons
Top expressed in olfactory tubercle hippocampus proper lateral septal nucleus globus pallidus nucleus accumbens anterior amygdaloid area lobe of cerebellum subiculum Region I of hippocampus proper prefrontal cortex
More reference expression data
BioGPS
Wikidata
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PP2BA ) is a protein that in humans is encoded by the PPP3CA gene .[ 5] [ 6]
References
Further reading
Crabtree GR (March 1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT" . Cell . 96 (5): 611– 4. doi :10.1016/S0092-8674(00)80571-1 . PMID 10089876 . S2CID 8817053 .
Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC (April 1999). "Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD". Science . 284 (5412): 339– 43. Bibcode :1999Sci...284..339W . doi :10.1126/science.284.5412.339 . PMID 10195903 .
Fuentes JJ, Genescà L, Kingsbury TJ, Cunningham KW, Pérez-Riba M, Estivill X, de la Luna S (July 2000). "DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways" . Human Molecular Genetics . 9 (11): 1681– 90. doi :10.1093/hmg/9.11.1681 . PMID 10861295 .
Frey N, Richardson JA, Olson EN (December 2000). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins" . Proceedings of the National Academy of Sciences of the United States of America . 97 (26): 14632– 7. Bibcode :2000PNAS...9714632F . doi :10.1073/pnas.260501097 . PMC 18970 . PMID 11114196 .
Siddiq A, Miyazaki T, Takagishi Y, Kanou Y, Hayasaka S, Inouye M, Seo H, Murata Y (May 2001). "Expression of ZAKI-4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism" . Endocrinology . 142 (5): 1752– 9. doi :10.1210/endo.142.5.8156 . PMID 11316738 .
Graef IA, Chen F, Chen L, Kuo A, Crabtree GR (June 2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature" . Cell . 105 (7): 863– 75. doi :10.1016/S0092-8674(01)00396-8 . PMID 11439183 . S2CID 5278706 .
Mukerjee N, McGinnis KM, Gnegy ME, Wang KK (August 2001). "Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation". Biochemical and Biophysical Research Communications . 285 (5): 1192– 9. CiteSeerX 10.1.1.414.4108 . doi :10.1006/bbrc.2001.5278 . PMID 11478781 .
Volkel H, Scholz M, Link J, Selzle M, Werner P, Tunnemann R, Jung G, Ludolph AC, Reuter A (August 2001). "Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin" . FEBS Letters . 503 (2– 3): 201– 5. doi :10.1016/S0014-5793(01)02730-2 . PMID 11513882 . S2CID 44432580 .
Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J (November 2001). "Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells" . The Journal of Experimental Medicine . 194 (10): 1449– 59. doi :10.1084/jem.194.10.1449 . PMC 2193671 . PMID 11714752 .
Frey N, Olson EN (April 2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins" . The Journal of Biological Chemistry . 277 (16): 13998– 4004. doi :10.1074/jbc.M200712200 . PMID 11842093 .