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| | | | | | | | Laodice of Macedonia | | Antiochus from Orestia, Macedonia | | Ptolemy somatophylax |
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| | | | | | | | 1.Apama daughter of Spitamenes satrap of Sogdiana | | Seleucus I Nikator emperor of Seleucid Empire 305–281 BC | | 2.Stratonice daughter of Demetrius I king of Macedonia | | Didymeia |
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| | | | | | | | Stratonice of Syria daughter of Demetrius I king of Macedonia | | (1) Antiochus I Soter emperor of Seleucid Empire 281–261 BC | | (1) Achaeus the Elder landowner in Asia Minor | | (2) Phila ∞ Antigonus II Gonatas king of Macedonia |
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Apama II ∞ Magas king of Cyrene | | Stratonice ∞ Demetrius II king of Macedon | | 2.Berenice daughter of Ptolemy II king of Egypt | | Antiochus II Theos emperor of Seleucid Empire 261–246 BC | | 1.Laodice I
| | Laodice II ∞ Seleucus II Callinicus | | Alexander landowner in Asia Minor | | Andromachus landowner in Asia Minor | | Antiochis ∞ Attalus Attalid dynasty |
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| | | | | | | | Laodice II daughter of Achaeus landowner in Asia Minor | | (1) Seleucus II Callinicus emperor of Seleucid Empire 246–225 BC | | (1) Antiochus Hierax ruler of Asia Minor | | (1) Stratonice ∞ Ariarathes III of Cappadocia | | (1) Laodice ∞ Mithridates II of Pontus | | Achaeus commander of Asia Minor | | Laodice daughter of Mithridates II of Pontus |
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| | | | Antiochis ∞ Xerxes king of Sophene & Commagene | | Seleucus III Ceraunus emperor of Seleucid Empire 225–223 BC | | Antiochus III the Great emperor of Seleucid Empire 222–187 BC | | Laodice III daughter of Mithridates II of Pontus |
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Cleopatra I Syra ∞ Ptolemy V of Egypt | | Antiochus co-emperor 210–193 BC | | Laodice IV ∞ 3.Antiochus IV Epiphanes | | Seleucus IV Philopator emperor of Seleucid Empire 187–175 BC | | Antiochus IV Epiphanes emperor of Seleucid Empire 175–164 BC | | Antiochis ∞ Ariarathes IV of Cappadocia | |
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Nyssa ∞ Pharnaces I of Pontus Mithridatic dynasty | | Antiochus emperor of Seleucid Empire 175–170 BC | | Laodice V ∞ Perseus king of Macedonia | | Demetrius I Soter emperor of Seleucid Empire 161–150 BC | | Antiochus V Eupator emperor of Seleucid Empire 164–161 BC | | Laodice VI ∞ Mithridates V of Pontus Mithridatic dynasty | | Laodice ∞ Mithridates III of Pontus | | Alexander Balas emperor of Seleucid Empire 152/150–146 BC | | Cleopatra Thea daughter of Ptolemy VI of Egypt |
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| | | | | | | | 2.Rhodogune of Parthia daughter of Mithridates I of Parthia | | Demetrius II Nicator emperor of Seleucid Empire 145–138 BC | | 1.Cleopatra Thea daughter of Ptolemy VI of Egypt queen of Syria 126–121 BC | | Antiochus VII Sidetes emperor of Seleucid Empire 138–129 BC | | | | | | Antiochus VI Dionysus emperor of Seleucid Empire 144–142/1 BC |
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| | | | (1) Seleucus V Philometor co-king of Syria 126–125 BC | | 1.Tryphaena daughter of Ptolemy VIII of Egypt | | (1) Antiochus VIII Grypus co-king of Syria 125–122 BC king of Syria 122–96 BC | | 2.Cleopatra Selene daughter of Ptolemy VIII of Egypt | | Antiochus IX Cyzicenus king of Syria 116–96 BC | | Cleopatra IV of Egypt daughter of Ptolemy VIII of Egypt | | Alexander II Zabinas king of Syria 128–123 BC | |
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(1) Seleucus VI Epiphanes king of Syria 96–94 BC | | (1) Antiochus XI Epiphanes king of Syria 94–93 BC | | (1) Laodice VII Thea ∞ Mithridates I Callinicus king of Commagene | | (1) Philip I Philadelphus king of Syria 94–83/75 BC | | (1) Demetrius III Eucaerus king of Syria 96–87 BC | | (1) Antiochus XII Dionysus king of Syria 87–82 BC | | Antiochus X Eusebes king of Syria 95–92/88 BC | | Cleopatra Selene daughter of Ptolemy VIII of Egypt |
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| | | | | | | | | | | | Philip II Philoromaeus king of Syria 65–64 BC | | | | | | Antiochus XIII Asiaticus king of Syria 69–64 BC | | Seleucus VII Philometor king of Syria 83–69 BC | | Berenice IV daughter of Ptolemy XII of Egypt |
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