Nwaneri saw limited action as a rookie during the Jaguars' 2007 playoff run, playing in 9 games with 1 start. The next season, he was elevated to starter after an injury to starting guard Vince Manuwai. In all, he appeared in 15 games during the 2008 season, starting 15 of them. He allowed 4.5 sacks during the season.
In 2009, Nwaneri and fellow guard Maurice Williams competed for the starting guard position opposite the returning Vince Manuwai. Nwaneri won the job; Williams was deactivated for much of the season before being released on December 5, 2009.[7] Nwaneri appeared in all 16 games, starting 13 of them. He was only credited with allowing one-half of a sack. Nwaneri was also not penalized during the 2009 season.
Nwaneri's most notable plays occurred in the 2011 season when he made two offensive fumble recoveries in separate games against the Carolina Panthers and the Baltimore Ravens.
Nwaneri signed with the Dallas Cowboys on June 25, 2014.[9] He was cut during final roster cuts on August 30, 2014.[10] Following his release, he chose to retire from the NFL.
Death
Nwaneri died on December 30, 2022. Preliminary results indicated a possible heart attack. He was 38.[11]