Frith's research paved the way for the recognition of a theory of mind deficit in autism.[22] In 1985, while she was a member of the Medical Research Council's Cognitive Development Unit (MRC-CDU) in London, she published with Alan M. Leslie and Simon Baron-Cohen the article "Does the autistic child have a 'theory of mind'?",[23] which proposed that people with autism have specific difficulties understanding other people's beliefs and desires. This paper used a false-belief task invented by Joseph Perner in 1983. Frith, and her colleagues,[24] created two theories of autism. The first is "lack of implicit mentalizing",[25] a lack of the ability to track others' mental state with a basis in the brain.[26] The second is "weak central coherence"[27] by which she suggested that individuals with autism are better than neurotypical people at processing details, but worse at integrating information from many different sources.[28] Frith was one of the first neuroscientists to recognize autism "as a condition of the brain rather than the result of cold parenting."[29]
She was one of the first people in the UK to study Asperger's syndrome,[30] at MRC-CDU London. Her work also focused on reading development, spelling and dyslexia.[16] Frith attacked the theory that dyslexia was linked to lack of intelligence[31] or caused by sensorimotor impairments.[32] In her book on spelling,[8] she pointed out that some people can be perfectly competent readers, but extremely poor spellers, a group of dyslexics not recognised before.[16] Her research, along with that of Maggie Snowling, showed that people with dyslexia tend to struggle with phonological processing.[33][31] In 1995 Frith, Paulesu, Snowling and colleagues conducted one of the first brain imaging studies with dyslexic adults showing that, while completing tasks requiring phonological processing, people with dyslexia show a lack of functional connectivity within the language network of the brain.[34]
Frith has been supported throughout her career by the Medical Research Council at University College London.[35] She was an active collaborator at the Interacting Minds Centre[36] at Aarhus University in Denmark. The goal of the centre is to provide a trans-disciplinary platform, upon which the many aspects of human interaction may be studied. The project is based in part on a paper written with Chris Frith: "Interacting Minds – a Biological Basis".[37]
Frith has encouraged the advancement of women in science, in part by developing a support network called Science & Shopping,[42] which she hopes will "encourage women to share ideas and information that are inspiring and fun."[43] She also co-founded the UCL Women[44] network, "a grassroots networking and social organization for academic staff (postdocs and above) in STEM at UCL", in January 2013.[45] In 2015 she was named chair of the Royal Society's Diversity Committee,[46] during which time she wrote about unconscious bias and how it affects which scientists receive grants.[47]
On 1 March 2013, she was the guest on BBC Radio 4's Desert Island Discs.[50] In 2013 Frith wrote on the visibility of women in science, by promoting an exhibition on female scientist portraits at The Royal Society.[51]
From 31 March to 4 April 2014, to coincide with World Autism Awareness Day on 2 April, she was the guest of Sarah Walker on BBC Radio 3's Essential Classics.[52] On 1 April 2014, she featured in "Living with Autism", an episode of the BBCHorizon documentary series.[53] On 26 August 2015, she presented the Horizon episode entitled "OCD: A Monster in my Mind".[54] On 29 August 2017, she presented the Horizon episode entitled "What Makes a Psychopath?".[55]
On 13 December 2017, she gave an interview to the Association for Child and Adolescent Mental Health,[56] in which she talked about her early life and her passion for autism research in children.[13]
^Houston, R. A.; Frith, Uta (2000). Autism in history: the case of Hugh Blair of Borgue [c. 1708–1765]. Cambridge, MA: Blackwell Publishers. ISBN978-0-631-22088-6.
^Korkiakangas, Terhi; Dindar, Katja; Laitila, Aarno; Kärnä, Eija (November 2016). "The Sally-Anne test: an interactional analysis of a dyadic assessment". International Journal of Language & Communication Disorders. 51 (6): 685–702. doi:10.1111/1460-6984.12240. ISSN1460-6984. PMID27184176.
^White, S., Milne, E., Rosen., Hansen,P., Swettenham, J., Frith, U. and Ramus, F. (2006). "The role of sensorimotor impairments in dyslexia: a multiple case study of dyslexic children". Developmental Science. 9 (3): 237–255. doi:10.1111/j.1467-7687.2006.00483.x. PMID16669791.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Paulesu, E., Frith, U., Snowling, M., Gallagher, A., Morris, J., Frackowiak, R. and Frith, C.D. (1995). "Is developmental dyslexia a disconnection syndrome? Evidence from PET scanning". Brain. 119: 143–158. doi:10.1093/brain/119.1.143. PMID8624677.{{cite journal}}: CS1 maint: multiple names: authors list (link)