The 2020–21 season was the 100th season in the existence of C.D. Santa Clara and the club's third consecutive season in the top-flight of Portuguese football. In addition to the domestic league, Santa Clara participated in this season's edition of the Taça de Portugal.
Players
First-team squad
As of 3 February 2021
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
^ abcBraga qualified for the Europa League group stage by winning the 2020–21 Taça de Portugal. Since they would have qualified for the Europa Conference League third qualifying round by finishing fourth, the berth was awarded to the fifth-placed team (Paços de Ferreira), and the Europa Conference League second qualifying round berth reserved to the fifth-placed team was awarded to the sixth-placed team (Santa Clara).
^ abVitória de Guimarães are ranked ahead of Moreirense on head-to-head points: Vitória de Guimarães 4, Moreirense 1.