DYRK3

DYRK3
Identifiers
Aliases	DYRK3, DYRK5, RED, REDK, hYAK3-2, dual specificity tyrosine phosphorylation regulated kinase 3
External IDs	OMIM: 603497; MGI: 1330300; HomoloGene: 55762; GeneCards: DYRK3; OMA:DYRK3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,684,419 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	131,066,077 bp
RNA expression pattern
	Top expressed in
	beta cell; ; left testis; ; right testis; ; male germ cell; ; sperm; ; vena cava; ; cartilage tissue; ; stromal cell of endometrium; ; apex of heart; ; mucosa of urinary bladder;
	Top expressed in
	seminiferous tubule; ; spermatid; ; fetal liver hematopoietic progenitor cell; ; spermatocyte; ; respiratory epithelium; ; nasal epithelium; ; olfactory epithelium; ; parotid gland; ; facial motor nucleus; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; nucleotide binding; ATP binding; magnesium ion binding; metal ion binding; kinase activity; protein serine/threonine kinase activity;
Cellular component	nucleus; nucleoplasm; cytosol; intracellular membrane-bounded organelle; cytoplasm; cytoplasmic stress granule; pericentriolar material; microtubule organizing center; cytoskeleton; nuclear speck;
Biological process	erythrocyte differentiation; protein phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; stress granule disassembly; negative regulation of apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; regulation of cellular response to stress; regulation of TORC1 signaling; cell cycle; nuclear speck organization; cell division; positive regulation of cell cycle G2/M phase transition; organelle disassembly;
	Sources:Amigo / QuickGO
Orthologs
	8444
	226419
	ENSG00000143479
	ENSMUSG00000016526
	O43781
	Q922Y0
	NM_001004023; NM_003582
	NM_145508
	NP_001004023; NP_003573
	NP_663483
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity tyrosine-phosphorylation-regulated kinase 3 is an enzyme that in humans is encoded by the DYRK3 gene.^[5]^[6]

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143479 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016526 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG (Nov 1998). "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases". J Biol Chem. 273 (40): 25893–902. doi:10.1074/jbc.273.40.25893. PMID 9748265.
^ ^a ^b "Entrez Gene: DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3".

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Zhang D, Li K, Erickson-Miller CL, et al. (2005). "DYRK gene structure and erythroid-restricted features of DYRK3 gene expression". Genomics. 85 (1): 117–30. doi:10.1016/j.ygeno.2004.08.021. PMID 15607427.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Li K, Zhao S, Karur V, Wojchowski DM (2003). "DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival". J. Biol. Chem. 277 (49): 47052–60. doi:10.1074/jbc.M205374200. PMID 12356771.
Lord KA, Creasy CL, King AG, et al. (2000). "REDK, a novel human regulatory erythroid kinase". Blood. 95 (9): 2838–46. doi:10.1182/blood.V95.9.2838.009k29_2838_2846. PMID 10779429.
Xia J, Yang X, Ruan Q, et al. (1999). "[Molecular cloning and characterization of novel protein kinase gene DYRK3]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 15 (6): 327–32. PMID 9845759.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143479 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016526 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9748265-5] Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG (Nov 1998). "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases". J Biol Chem. 273 (40): 25893–902. doi:10.1074/jbc.273.40.25893. PMID 9748265.

[entrez-6] "Entrez Gene: DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3".

[1]

[2]

[3]

[4]

[5]

[6]

DYRK3

See also

References

Further reading