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FGGY carbohydrate kinase family

FGGY family of carbohydrate kinases, N-terminal domain
enterococcus casseliflavus glycerol kinase complexed with glycerol
Identifiers
SymbolFGGY_N
PfamPF00370
Pfam clanCL0108
InterProIPR018484
PROSITEPDOC00408
SCOP21gla / SCOPe / SUPFAM
CDDcd00366
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
FGGY family of carbohydrate kinases, C-terminal domain
escherichia coli glycerol kinase mutant with bound atp analog showing substantial domain motion
Identifiers
SymbolFGGY_C
PfamPF02782
Pfam clanCL0108
InterProIPR018485
PROSITEPDOC00408
SCOP21gla / SCOPe / SUPFAM
CDDcd00366
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology the FGGY carbohydrate kinase family is a family of evolutionarily related carbohydrate kinase enzymes. These enzymes include L-fuculokinase EC 2.7.1.51 (gene fucK); gluconokinase EC 2.7.1.12 (gene gntK); glycerol kinase EC 2.7.1.30 (gene glpK); xylulokinase EC 2.7.1.17 (gene xylB); D-ribulose kinase EC 2.7.1.47 (gene FGGY/YDR109c);[1] and L-xylulose kinase EC 2.7.1.53 (gene lyxK). These enzymes are proteins of from 480 to 520 amino acid residues.

These enzymes consist of two domains. The N-terminal and C-terminal domains both adopt a ribonuclease H-like fold and are structurally related to each other.[1][2][3]

References

  1. ^ a b Singh C, Glaab E, Linster C (2016). "Molecular Identification of D-Ribulokinase in Budding Yeast and Mammals". J. Biol. Chem. 292 (3): 1005–1028. doi:10.1074/jbc.M116.760744. PMC 5247636. PMID 27909055.
  2. ^ Hurley JH, Faber HR, Worthylake D, Meadow ND, Roseman S, Pettigrew DW, Remington SJ (January 1993). "Structure of the regulatory complex of Escherichia coli IIIGlc with glycerol kinase". Science. 259 (5095): 673–7. Bibcode:1993Sci...259..673H. doi:10.1126/science.8430315. PMID 8430315. S2CID 20908371.
  3. ^ Ormo M, Bystrom CE, Remington SJ (November 1998). "Crystal structure of a complex of Escherichia coli glycerol kinase and an allosteric effector fructose 1,6-bisphosphate". Biochemistry. 37 (47): 16565–72. doi:10.1021/bi981616s. PMID 9843423.
This article incorporates text from the public domain Pfam and InterPro: IPR018485
This article incorporates text from the public domain Pfam and InterPro: IPR018484
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