IGFBP2

IGFBP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H7T
Identifiers
Aliases	IGFBP2, IBP2, IGF-BP53, insulin like growth factor binding protein 2
External IDs	OMIM: 146731; MGI: 96437; HomoloGene: 499; GeneCards: IGFBP2; OMA:IGFBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	216,664,436 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	72,891,633 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; decidua; ; right coronary artery; ; body of stomach; ; ventricular zone; ; ganglionic eminence; ; olfactory zone of nasal mucosa; ; epithelium of bronchus; ; bronchial epithelial cell;
	Top expressed in
	choroid plexus of fourth ventricle; ; calvaria; ; vestibular sensory epithelium; ; Epithelium of choroid plexus; ; corneal stroma; ; efferent ductule; ; optic nerve; ; transitional epithelium of urinary bladder; ; left lobe of liver; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	insulin-like growth factor binding; growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding; signaling receptor binding;
Cellular component	extracellular region; apical plasma membrane; extracellular exosome; cytoplasmic vesicle; extracellular space;
Biological process	response to estradiol; response to retinoic acid; response to nutrient; female pregnancy; response to steroid hormone; response to mechanical stimulus; ageing; response to glucocorticoid; response to lithium ion; response to estrogen; regulation of insulin-like growth factor receptor signaling pathway; cellular response to hormone stimulus; regulation of cell growth; regulation of growth; negative regulation of canonical Wnt signaling pathway; signal transduction; positive regulation of activated T cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3485
	16008
	ENSG00000115457
	ENSMUSG00000039323
	P18065
	P47877
	NM_001313990; NM_001313992; NM_001313993; NM_000597
	NM_008342; NM_001310659
	NP_000588; NP_001300919; NP_001300921; NP_001300922
	NP_001297588; NP_032368
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor-binding protein 2 is a protein that in humans is encoded by the IGFBP2 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115457 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039323 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zapf J, Kiefer M, Merryweather J, Musiarz F, Bauer D, Born W, Fischer JA, Froesch ER (Oct 1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia". J Biol Chem. 265 (25): 14892–8. doi:10.1016/S0021-9258(18)77200-1. PMID 1697583.

Rajaram S, Baylink DJ, Mohan S (1997). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions". Endocr. Rev. 18 (6): 801–31. doi:10.1210/edrv.18.6.0321. PMID 9408744.
Wolf E, Lahm H, Wu M, et al. (2000). "Effects of IGFBP-2 overexpression in vitro and in vivo". Pediatr. Nephrol. 14 (7): 572–8. doi:10.1007/s004670000362. PMID 10912521. S2CID 5823615.
Chesik D, De Keyser J, Wilczak N (2007). "Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis". Cytokine Growth Factor Rev. 18 (3–4): 267–78. doi:10.1016/j.cytogfr.2007.04.001. PMID 17485236.
Binkert C, Margot JB, Landwehr J, et al. (1992). "Structure of the human insulin-like growth factor binding protein-2 gene". Mol. Endocrinol. 6 (5): 826–36. doi:10.1210/mend.6.5.1376411. PMID 1376411. S2CID 20288398.
Zhou J, Bondy C (1992). "Insulin-like growth factor-II and its binding proteins in placental development". Endocrinology. 131 (3): 1230–40. doi:10.1210/endo.131.3.1380437. PMID 1380437.
Ehrenborg E, Vilhelmsdotter S, Bajalica S, et al. (1991). "Structure and localization of the human insulin-like growth factor-binding protein 2 gene". Biochem. Biophys. Res. Commun. 176 (3): 1250–5. doi:10.1016/0006-291X(91)90420-C. PMID 1710112.
Agarwal N, Hsieh CL, Sills D, et al. (1991). "Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2)". Exp. Eye Res. 52 (5): 549–61. doi:10.1016/0014-4835(91)90056-K. PMID 1712312.
Roghani M, Lassarre C, Zapf J, et al. (1991). "Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins". J. Clin. Endocrinol. Metab. 73 (3): 658–66. doi:10.1210/jcem-73-3-658. PMID 1714916.
Clemmons DR, Snyder DK, Busby WH (1991). "Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects". J. Clin. Endocrinol. Metab. 73 (4): 727–33. doi:10.1210/jcem-73-4-727. PMID 1716260.
Roghani M, Segovia B, Whitechurch O, Binoux M (1993). "Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species". Growth Regul. 1 (3): 125–30. PMID 1726837.
Rosenfeld RG, Pham H, Conover CA, et al. (1989). "Structural and immunological comparison of insulin-like growth factor binding proteins of cerebrospinal and amniotic fluids". J. Clin. Endocrinol. Metab. 68 (3): 638–46. doi:10.1210/jcem-68-3-638. PMID 2465304.
Binkert C, Landwehr J, Mary JL, et al. (1989). "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)". EMBO J. 8 (9): 2497–502. doi:10.1002/j.1460-2075.1989.tb08386.x. PMC 401241. PMID 2479552.
Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544. S2CID 22503525.
Zhou J, Bondy C (1993). "Anatomy of the human ovarian insulin-like growth factor system". Biol. Reprod. 48 (3): 467–82. doi:10.1095/biolreprod48.3.467. PMID 7680905.
Han VK, Bassett N, Walton J, Challis JR (1996). "The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface". J. Clin. Endocrinol. Metab. 81 (7): 2680–93. doi:10.1210/jcem.81.7.8675597. PMID 8675597. S2CID 33861826.
Bach LA, Rechler MM (1996). "Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography". Biochim. Biophys. Acta. 1313 (1): 79–88. doi:10.1016/0167-4889(96)00053-5. PMID 8781553.
Ho PJ, Baxter RC (1997). "Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia". Clin. Endocrinol. 46 (3): 333–42. doi:10.1046/j.1365-2265.1997.1100922.x. PMID 9156044. S2CID 23145708.
Wong MS, Fong CC, Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins". Biochim. Biophys. Acta. 1432 (2): 293–301. doi:10.1016/S0167-4838(99)00106-5. PMID 10407151.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115457 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039323 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1697583-5] Zapf J, Kiefer M, Merryweather J, Musiarz F, Bauer D, Born W, Fischer JA, Froesch ER (Oct 1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia". J Biol Chem. 265 (25): 14892–8. doi:10.1016/S0021-9258(18)77200-1. PMID 1697583.

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IGFBP2

References

Further reading